Nicotinamide Riboside (NR) is a recently discovered form of vitamin B3.This is a potentially new Complementary and Alternative Medicine treatment for Type 2- diabetes. Nicotinamide riboside naturally occurs in yeast, bacteria, and mammals. It has recently been promoted as an anti-ageing natural medicine by some practitioners of Complementary and Alternative Medicine. Phytochemicals are common Complementary and Alternative Medicine treatment for many disorders. NR can only be obtained under the brand name of Niagen and is available for the phytochemical company in the US called Chromadex. For more information about the treatment you can call us at 0405 845 763 .
Phytochemicals are commonly used as Complementary and Alternative Medicine treatment for many disorders. NAR can only be obtained under the brand name of Niagen and is available for the phytochemical company in the US called Chromadex.
Nicotinamide Riboside (NR)
Vitamin B3 is one of B vitamins that is prescribed by many practitioners of Complementary and Alternative Medicine for various ailments. It is also known as niacin /nicotinic acid and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate.Nicotinamide riboside (NAR) is a precursor to vitamin B3 and may represent a breakthrough in Complementary and Alternative Medicine as some (CAM) practitioners prescribe it as an anti-ageing supplement. We know that NAD+ decreases with age, so the rationale is that through supplementation of NR, the levels of NAD+ increase. Animal studies have shown that supplementation of NR promotes mitochondrial biogenesis i.e. formation of new mitochondria. Mitochondria is the “cell’s powerhouse” generating chemical energy to carry out essential biological functions. Mitochondrial dysfunction is associated with several diseases associated with aging such as Alzheimer’s disease and Type-2 diabetes. For example, in vivo tests have shown that Nicotinamide riboside-treated animals experience a 50% induction of PGC1a mRNA levels; reduced PGC-1a levels are found in Alzheimer’s brains, therefore, it follows that nicotinamide may be a molecule of interest in treating Alzheimer’s disease.
As we age the ability for absorbing and using blood glucose decreases i.e. s glucose intolerance. This inevitably leads to a state of pre-diabetes. Glucose intolerance tests are used in Conventional and Complementary and Alternative Medicine healthcare to confirm pre-diabetes/type 2 diabetes . It includes anyone with either:
- A fasting blood glucose level of above 6.0 mmol/L
- A blood glucose level of over 7.8 mmol/L 2 hours after consuming 75g of glucose
Symptoms of glucose intolerance are similar to Type 2 Diabetes and include:
- Dry mouth
- Extreme fatigue
- Blurred vision
- Feeling very thirsty
- Frequent urination
- Decreased muscle mass
Current Conventional and Complementary and Alternative Medicine thinking point to increased insulin resistance that occurs with aging. This increase in insulin resistance is as a result of:
- increased adiposity
- decreased lean muscle mass
- altered dietary habits with aging and:
- reduced physical exercise.
As NAR increases insulin sensitivity it makes it a viable molecule for Complementary and Alternative Medicine .
A recent study from the University of Iowa has now shown that NAR in mice with prediabetes and type 2 diabetes can:
- lower blood sugar levels
- reduce fatty liver, and
- prevent peripheral nerve damage
These mice were fed with NR supplement for the last eight weeks of the 21-week experiment. The NR protected:
- prediabetic and type 2 mice from weight gain when administered a high-fat diet
- high-fat fed mice from hepatic steatosis and build-up of fat globules in the liver
As practitioners of Complementary and Alternative Medicine, we know that many of our clients/patients with type 2 Diabetes or prediabetes have neuropathy or peripheral nerve damage with around 60-70% of diabetics having some form of neuropathy. Peripheral neuropathy is a leading cause of diabetic foot ulcers and limb amputation in people with Type 2 Diabetes.NR also protected against peripheral nerve damage or neuropathy.
Nicotinamide riboside has long been known as a possible NADþ precursor, it is only now that its unique biological properties have been popularized through Complementary and Alternative Medicine companies like Chromadex. These recent findings may provide effective Complementary and Alternative Medicine treatment for several metabolic disorders such as:
- Type 2 diabetes
- Fatty liver disease
This Complementary and Alternative Medicine study was funded by the Fraternal Order of Eagles Diabetes Research Center at the UI, the Roy J. Carver Charitable Trust, the National Institutes of Health, and the Department of Veterans Affairs.
This is encouraging news for Complementary and Alternative Medicine. We await the human trial data with much anticipation,if successful, then integration of NR with Complementary and Alternative Medicine therapies, food and nutrition advice and lifestyle advice may provide better treatment efficacy for Type 2 diabetes.
So why you are waiting for to know more call us at 0405 845 763 right now.